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Maria del Mar Vergel
Maria del Mar Vergel
Spain
Publications
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Review Article
Cellular Senescence as a Barrier to Environmental Carcinogenesis
Author(s): Maria del Mar Vergel and Amancio CarneroMaria del Mar Vergel and Amancio Carnero
The first cellular response to a carcinogen is a cell cycle arrest program that may end in a permanent arrest with features of cellular senescence. This may be an evolutionary conserved response to delay environmental-induced cancer until the replicative life of the organism has ended. With the concomitant alteration of genes involved in cellular senescence, which promotes cellular immortalization, a further carcinogenic insult may increase the chances of tumorigenesis and the development of a malignant clone. Therefore, understanding cellular senescence and how it can be modified by environmental carcinogens, including food, may be essential for controlling the increase of cancer prevalence. .. View More»
DOI: 10.4172/2157-2518.S3-004