Journal of Clinical & Experimental Pharmacology

Marcel A Schijf

Publications

• Research Article
  A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone
  Author(s): Geertje JD van Mierlo *,C Frieke Kuper ,Mary-Lène de Zeeuw-Brouwer ,Marcel A Schijf ,Joost P Bruijntjes ,Marlies Otto ,Niels- Christian Ganderup ,André H PenninksGeertje JD van Mierlo *,C Frieke Kuper ,Mary-Lène de Zeeuw-Brouwer ,Marcel A Schijf ,Joost P Bruijntjes ,Marlies Otto ,Niels- Christian Ganderup ,André H Penninks
  
  Introduction: There is a growing interest in the minipig as a non-rodent species in the safety assessment of (bio) pharmaceuticals and (agro) chemicals. For (bio) pharmaceuticals the need to evaluate the potential adverse effects on the immune system is an increasingly important aspect of safety evaluation. In the present study, cyclosporin A and Dexamethasone were used as model compounds to examine whether the regulatory endpoints requested for immunotoxicity testing can be tested in the Göttingen minipig. Methods: Minipigs were treated with vehicle, 20 mg/kg/day cyclosporine A or 0.4 mg/kg/day dexamethasone for 39 (males) or 40 (females) consecutive days. Clinical signs, body weight, hematology, lymphocyte subset analysis in peripheral blood mononuclear cells, Natural Killer cell activity, primary and secondary antibody response and Dela.. View More»
  DOI: 10.4172/2161-1459.S4-006

  Abstract PDF