Journal of Clinical & Experimental Pharmacology

Judith A Clements

Biography

Distinguished Professor Clements has over 30 years of experience as a molecular and cell biologist in the endocrine field with expertise in neuroendocrine functional peptides and proteases – particularly the kallikrein-like serine protease family - in hormone dependent cancers, with a major emphasis on prostate cancer. She has published over 190 articles in refereed international journals and book chapters and has an H-index of 45 with >7000 career citations (Google Scholar). Her research covers the spectrum of biochemistry, cellular and molecular biology, using both in vitro and in vivo cell models, and includes proteomic, transcriptomic and genetic studies and the development and use of 3-dimensional cell culture systems better mimicking the tumour microenvironment. Her work encompasses understanding the regulation of endocrine/paracrine and autocrine mechanisms underpinning prostate cancer maintenance and progression and the identification of potential new diagnostic, prognostic and therapeutic targets. She is internationally recognised as an expert in her field and has been awarded the Silver and Gold medals of the international Frey-Werle Foundation for her work. She leads the Queensland node of the international PRACTICAL consortium, has led the Australian Prostate Cancer BioResource (tissue bank) for more than 10 years and is Chair of the Queensland Board of the PCFA.

Research Interest

Functional role of PSA and the related Kallikrein proteases in prostate and ovarian cancer Role of variant Kallikrein isoforms in cancer Role of Kallikrein proteases in bone metastasis Predictive and prognostic biomarker potential of Kallikrein proteases Functional role of genetic variation in the Kallikrein locus Tumor-microenvironment influences in prostate and ovarian cancer Bioengineered three dimensional in vitro and in vivo models of prostate and ovarian cancer progression.