Journal of Neonatal Biology

Juan Antonio Gonzalez-Barrios

Publications

• Research Article
  Functional Polymorphism of the Interleukin-1beta Gene Promoter is Associated with Increased Risk for Cerebral Palsy in Mexican Children with Perinatal Hypoxia-Ischemia Antecedents
  Author(s): Sofia Torres-Merino, María del Rocío Thompson-Bonilla, Bertha Alicia León-Chávez, Daniel Martínez-Fong and Juan Antonio González-Barrios Sofia Torres-Merino, María del Rocío Thompson-Bonilla, Bertha Alicia León-Chávez, Daniel Martínez-Fong and Juan Antonio González-Barrios
  
  Background: The genetic polymorphism that contributes to the development of infantile cerebral palsy (ICP) after a perinatal hypoxia-ischemia episode remains unknown. Because IL-1? plays a crucial role in the pathogenesis of hypoxic-ischemic encephalopathy, we evaluated whether the interleukin 1, beta (IL-1?) promoter single-nucleotide polymorphisms (SNPs) correlate with the increased risk for ICP following a perinatal hypoxia-ischemia. We assessed -511 C>T and -31 T>C IL-1? SNPs known to be involved in IL-1? expression. Methods: Genomic DNAs were purified from peripheral leukocytes of 48 ICP patients and 57 healthy children, amplified by using polymerase chain reaction (PCR), and then analyzed by using the restriction-fragment-length polymorphism technique. The SNP genotypes were established using real time PCR and validated with.. View More»
  DOI: 10.4172/2167-0897.1000.167

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