Journal of Clinical & Experimental Pharmacology

Ibarra-Hernandez JM

Publications

• Research Article
  Bupropion Cannot Reduce Acute Kidney Injury Due to Ischemia-Reperfusion
  Author(s): Guzmán-de la Garza FJ*,Cabello-García AJ,Ibarra-Hernandez JM,Martini-Antonio MT,Alarcón-Galván G,Cámara-Lemaroy CR,Vargas-Villarreal J,Hernández SG,Garza JC,Muzquiz-Vidales R,Cordero-Perez P,Garza NEF,Salinas-Martinez AM Guzmán-de la Garza FJ*,Cabello-García AJ,Ibarra-Hernandez JM,Martini-Antonio MT,Alarcón-Galván G,Cámara-Lemaroy CR,Vargas-Villarreal J,Hernández SG,Garza JC,Muzquiz-Vidales R,Cordero-Perez P,Garza NEF,Salinas-Martinez AM
  
  Bupropion can limit the increase of TNF-alpha, reducing the inflammatory response and injury due to Ischemia- Reperfusion (I/R) on tissues such as the bowel. Our objective was to evaluate bupropion as a preconditioning agent for ischemic acute kidney injury. Experiments were performed on female Wistar rats. Bupropion groups received 25 mg/kg 60 min before the maneuver. As a first step, 30 rats with a right nephrectomy were divided into 6 groups (n=5): sham 24, sham 48, bupropion 24, bupropion 48, ischemia-reperfusion 24 and ischemia-reperfusion 48. After 60 min of ischemia (except sham groups) 24 or 48 h of reperfusion was allowed. During a second step, 30 rats, with both kidneys conserved, were divided into 6 groups (n=5): sham 3, sham 72, bupropion 3, bupropion 72, ischemia-reperfusion 3, and ischemia-reperfusion 72 (IR72). Ischemia in these groups (except sham groups) was.. View More»
  DOI: 10.4172/2161-1459.1000239

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