Journal of Clinical & Experimental Pharmacology

Esume CO

Publications

• Research Article
  Single Adult-human Equivalent Dose of Intramuscular Chloroquine did not Lower Blood Glucose Level in Fasted Wistar Rats
  Author(s): Ejebe DE*,Esume CO,Nwokocha CR,Kagbo HD,Okolo AC,Emuesiri VD Ejebe DE*,Esume CO,Nwokocha CR,Kagbo HD,Okolo AC,Emuesiri VD
  
  Objectives: The 4-Aminoquinoline, Chloroquine is still indicated for treatment of malaria fever due to sensitive Plasmodium species. The hypoglycemic effects of Chloroquine have been sparsely reported in human and animal models of type 2 diabetes and a widely held perception among health caregivers in this part of the world is that administering intramuscularly Chloroquine to fasting malaria patients could be complicated by syncope directly caused by hypoglycemia. This study investigated the effects of a single adult human intramuscular bolus of Chloroquine on the blood glucose level in fasting normoglycemic Wistar rats. Methods: Fifteen acclimatized adult male rats were randomly divided into three groups of 5 per group. Group I and II rats were fasted overnight and received 4.17 mg/kg of intramuscular Chloroquine in the morning. Group III rats were also fasted but received 1ml of steri.. View More»
  DOI: 10.4172/2161-1459.1000213

  Abstract PDF