Journal of Clinical & Experimental Pharmacology

Durisova M

Publications

• Research Article
  Computational Investigation of Time Dependent Changes in the Formation of 7-Hydroxymethotrexate from Methotrexate in Patients Undergoing Treatment for Psoriasis with Methotrexate
  Author(s): Durisova MDurisova M
  
  Objective: To investigate time dependent changes in the formation of 7-hydroxymethotrexate (7OH-MTX) from methotrexate (MTX) in patients undergoing treatment for psoriasis with MTX. Method: This study is a companion piece of the study by Chladek et al. therefore the data from the study cited here was used. For modeling purposes a modeling method based on the theory of dynamic systems was employed. Results: The metabolic ratios of MTX to 7OH-MTX in plasma were constant during the first three months of the treatment of the patients for psoriasis with MTX. However, the mean time of the formation of 7OH-MTX from MTX increased from the value of about 9.35 h in the first phase of treatment to the value of about 15.59 in the third phase of treatment. The rate of the formation of 7OH-MTX from MTX decreased from 0.51/h to 0.29 1/h during the same time interval. Conclusions: All models developed; .. View More»
  DOI: 10.4172/2161-1459.1000205

  Abstract PDF