Journal of Clinical & Experimental Pharmacology

Durisova M

Biography

Durisova M is serving at an esteemed academic position in the Division of Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea. He is the recipient of numerous awards for his expert research works in related fields. His research interests reflect in his wide range of publications in various national and international journals.

Research Interest

To investigate time dependent changes in the formation of 7-hydroxymethotrexate (7OH-MTX) from methotrexate (MTX) in patients undergoing treatment for psoriasis with MTX. Method: This study is a companion piece of the study by Chladek et al. therefore the data from the study cited here was used. For modeling purposes a modeling method based on the theory of dynamic systems was employed. Results: The metabolic ratios of MTX to 7OH-MTX in plasma were constant during the first three months of the treatment of the patients for psoriasis with MTX. However, the mean time of the formation of 7OH-MTX from MTX increased from the value of about 9.35 h in the first phase of treatment to the value of about 15.59 in the third phase of treatment. The rate of the formation of 7OH-MTX from MTX decreased from 0.51/h to 0.29 1/h during the same time interval. Conclusions