Gerontology & Geriatric Research

Domenico Pirritano

Publications

• Review Article
  The Role of Quetiapinein the Treatment of Alzheimer's Disease
  Author(s): Pietro Gareri, Luca Gallelli, Domenico Pirritano, Pierandrea Rende, Caterina Palleria, Emilio Russo, Alberto Castagna, Amalia Cecilia Bruni, Santo Gratteri and Giovambattista De SarroPietro Gareri, Luca Gallelli, Domenico Pirritano, Pierandrea Rende, Caterina Palleria, Emilio Russo, Alberto Castagna, Amalia Cecilia Bruni, Santo Gratteri and Giovambattista De Sarro
  
  Behavioral and psychological symptoms in dementia (BPSD) include an array of neuropsychiatric symptoms, such as delusions, hallucinations, aggression, and agitation. In recent years, the use of antipsychotics, both conventional and atypical, has been widely debated because of concerns about their safety in treating behavioral disturbances in elderly patients affected with dementia, and the possible risks for stroke and sudden death. In this review we described the pharmacokinetic of quetiapine, its correlation in patients with Alzheimer’s disease and its possible role in BPSD. Quetiapine has a bioavailability of 5-13%, about 83% is bound to plasma protein and is largely metabolized in the liver through CYP3A4, the mean plasma half-life is about 6 hand clearance is reduced by 40% in the elderly. Usually CYP3A4 inhibitors are able to increase the plasma levels of quetiapine, while.. View More»
  DOI: 10.4172/2167-7182.1000197

  Abstract PDF