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Cecilio Álamo
Cecilio Álamo
Spain
Publications
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Research Article
CYP450 and Its Implications in the Clinical Use of Antipsychotic Drugs
Author(s): Fernando Mora,Juan D Molina,Elena Zubillaga,Francisco López-Muñoz,Cecilio ÃÂlamoFernando Mora,Juan D Molina,Elena Zubillaga,Francisco López-Muñoz,Cecilio Ãlamo
Polypharmacy implies a high potential for drug-drug interactions. The capacity of the cytochrome P450 enzyme system involved in the metabolism of psychoactive drugs differs greatly, which leads to variable drug elimination rates and inter-subject differences in serum drug concentrations. Polymorphisms in genes coding for CYP450 enzymes contribute to this inter-subject variability. Therapeutic response and adverse effects vary among patients treated with the same dose of a certain drug. Polypharmacy, comorbidity and the use of certain substances (grapefruit juice, caffeine and tobacco) increase the chances of clinically relevant interactions in a psychotic patient. Choosing drugs with low interaction potential seems to be the best strategy to prevent clinically relevant interactions particularly in elderly, polymedicated, oncologic and HIV patients. .. View More»
DOI: 10.4172/2161-1459.1000176