Journal of Clinical & Experimental Pharmacology

Bernhard Hellwig

Publications

• Research Article
  Spectral and Higher-Order-Spectral Analysis of Tremor Time Series
  Author(s): Malenka Mader, Juliane Klatt, Florian Amtage, Bernhard Hellwig, Wolfgang Mader, Linda Sommerlade and Björn SchelterMalenka Mader, Juliane Klatt, Florian Amtage, Bernhard Hellwig, Wolfgang Mader, Linda Sommerlade and Björn Schelter
  
  Objectives: The aim of this study was to investigate linear and nonlinear properties of tremor time series. To this end, we applied linear (second order) and nonlinear (higher order) spectral and cross-spectral analysis to 58 Electroencephalographic (EEG) and Electromyographic (EMG) tremor recordings of seven essential and five Parkinsonian Tremor patients. Methods: Second and third order spectral analysis was performed on two types of data. First, data was simulated from a model mimicking the nonlinear properties of the tremor time series. Limitations of linear second order spectral analysis are illustrated in those simulations. Those limitations can be overcome by nonlinear third order spectral analysis. Second, tremor recordings from the trembling hand and contralateral motor area of the brain of the tremor patients were analyzed both by second and third order spectral analysis. Re.. View More»
  DOI: 10.4172/2161-1459.1000149

  Abstract PDF