Gerontology & Geriatric Research

Ben A. Bahr

Publications

• Commentary
  A One-Drug Strategy is Needed to Attenuate the Multi-Proteinopathy that Leads to Age-Related Diseases
  Author(s): Ben A. Bahr Ben A. Bahr
  
  Alzheimer’s disease (AD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS) are age-related protein accumulation disorders. They exhibit multi-proteinopathy involving tau and TAR DNA-binding protein 43 (TDP43), and the latter two disorders can also accumulate fused in sarcoma protein (FUS). AD is the most common multi-proteinopathy with an additional and perhaps key pathogenic contributor being the Aβ42 peptide. AD can also exhibit the accumulation of α-synuclein, a key protein that accumulates in Parkinson’s disease (PD) and related Lewy body diseases. The specific disorders that constitute FTD have a high proportion of familial or inherited cases, whereas less than 5% of AD cases and 5-10% of ALS cases are the familial inherited form, and the cause of the remaining 90-95% of sporadic AD and ALS cases is not fully understood. Many of the mo.. View More»
  DOI: 10.4172/2167-7182.1000212

  Abstract PDF