Journal of Clinical & Experimental Pharmacology

Ayoman Thierry-Lenoir Djadji

Publications

• Research Article
  Relationship between Efavirenz plasma concentrations and CYP2B6 Polymorphism in HIV/TB co-infected Africans taking rifampicin in the treatment Antituberculosis at Abidjan.
  Author(s): Ayoman Thierry-Lenoir DjadjiAyoman Thierry-Lenoir Djadji
  
  Aim: To investigate polymorphisms cytochrome 2 B6 and concomitant rifampicin use on the plasma concentration of Efavirenz 600 mg vs. 800 mg on HIV-infected Ivoirians. Methods: Consenting African patients with TB and HIV have received antiretroviral therapy including Efavirenz 600 and 800 mg, with rifampicin were observed. Efavirenz exposure was performed by HPLC MS-MS and Fluorimetric 5’ nuclease genotyping Assay (Atman Assays. Applied Biosystems Foster City, CA, USA) was used to genetic determination. Results: 19 randomized patients undergone genotyping, the median age was 34 years [30-41], 09 (47%) of women, the median weight was 55 kg, with extremes [49-62], the rate basic of CD4 were 173/mm3 . The viral load was 6.10 log10 in basic (5.66 - 6.42), the Akan ethnic group was essential in our sample with 10 (52.65%.. View More»
  DOI: 10.4172/2161-1459.1000185

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