Recent Developments in Gene Chemistry

Bhadury PS

The recent adavancement in the field of nucleic acid, nucleotide, and nucleoside has revolutionized modern day biological and chemical research. The knowledge of synthetic chemistry is essential to prepare modified nucleic acids as potent therapeutic agents and as tools for molecular biology. On the other hand with the help of combinatorial chemistry nucleic acid/peptide libraries are generated and then specific members are enriched and mutated to obtain the most promising chiral catalyst for achieving the desired asymmetric transformations which include regio- and stereoselective transformations of achiral precursors in typical carbon-carbon bond forming and DNAphosphorylation reactions.