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Abstract
Diagnostic Value of Multimodal Ultrasound in Cytological Diagnosis of Indeterminate Thyroid Nodules
Ruijuan Huang*, Shuzhen Cong, Yanyan Liang, Zhenyi Lin
Background: This study aimed to investigate the discriminative diagnostic potential of multimodal Ultrasound (US) for thyroid nodules displaying Indeterminate Cytological (IC) characteristics.
Methods: A total of 61 thyroid nodules (Bethesda III/IV/V) that underwent both fine needle aspiration biopsy and surgical intervention were examined, comprising 37 malignant and 24 benign nodules. Distinctions in sonographic features between benign and malignant nodules were evaluated. Logistic regression analysis was conducted to establish prediction models utilizing conventional US, Superb Microvascular Imaging (SMI), Ultrasound Elastography (UE), and multimodal US. The assessment of sensitivity, specificity, and accuracy in identifying malignant thyroid nodules with IC was carried out for conventional US, SMI, UE, and multimodal US. Receiver Operating Characteristic (ROC) curves were generated, and the Area Under the Curve (AUC) values were computed and compared.
Results: The sensitivity, specificity, and accuracy rates were as follows: 62.05%, 64.86%, and 63.93% for conventional US; 70.83%, 72.97%, and 72.13% for SMI; 83.33%, 83.78%, and 83.61% for UE; and 91.67%, 91.89%, and 91.80% for multimodal US, respectively. The AUC values for evaluating benign and malignant thyroid nodules with IC were as follows: 63.7% for conventional US, 71.9% for SMI, 83.6% for UE, and 86.70% for multimodal US. Multimodal US exhibited the highest diagnostic efficacy in identifying malignant nodules.
Conclusions: Preliminary clinical findings indicate that conventional US, SMI, and UE hold diagnostic value in distinguishing thyroid nodules with IC. Multimodal US imaging enhances diagnostic efficacy for identifying malignant nodules and provides additional insights into the differentiation between benign and malignant nodules.
Published Date: 2025-01-20; Received Date: 2023-09-06