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Rajagopal appavu
Rajagopal appavu
Rajagopal appavu is working under Department of Pharmacology and Toxicology Sealy Center for Vaccine Development University of Texas Medical Branch-Galveston, Texas
Biography
Department of Pharmacology and Toxicology Sealy Center for Vaccine Development University of Texas Medical Branch-Galveston, Texas
Research Interest
Broad curiosity in development of peptide/proteins as vaccine candidates, which includes protein-protein interaction analysis, synthesis of small molecules (organic/ inorganic/natural products), peptides (cyclic/acyclic disulfide bond formation), synthetic proteins via native chemical ligation approach, solution and solid-phase peptide synthesis and introduction of diverse chemical bonds in synthetic proteins, Structural determination of protein-DNA (Solid: X-ray, Solution: 2D & 3D NMR, and Gas: Mass Spectrometry) interactions and their pathways, stability, dynamics, and function, Molecular modeling and structure based drug design. Design, synthesis, and development of MRI contrast agents, Molecular mechanism of intracellular traffic (endocytosis and exocytosis) incorporation ligand free-bound. Further, biophysics and biochemistry of nanoparticle peptide disease targets.