Biochemistry & Analytical Biochemistry

Weight management intervention in overweight and obese Mongolian adults with newly diagnosed type-2 diabetes

International Conference on Biochemistry, Proteomics & Bioinformatics

May 16-17, 2018 Singapore

Bolormaa Vandanmagsar, Sainbileg Sonomtseren, Yanjmaa Sankhuu and Jaycob D Warfel

Pennington Biomedical Research Center, USA
National University of Medical Sciences, Mongolia
State Central Clinical Hospital, Mongolia

Posters & Accepted Abstracts: Biochem Anal Biochem

Abstract:

We evaluated the effectiveness of a weight loss intervention in Mongolian adults with newly diagnosed type-2 diabetes mellitus and with BMI-25.0 kg/m2, the first study of its kind to be conducted in Mongolia. 80 participants (33 men and 47 women) aged 32-56 years old received education sessions to improve nutritional habits and increase physical activity. Participants were counseled in-person on two occasions with regular follow-up by phone to eat less (reduce calorie intake by 30-40% and consume fewer fatty foods), shift food intake to earlier in a day and increase physical activity such as walking, jogging, running and biking. After 6 months, the average weight loss was 4.3±4.7 kg, representing a 4.9±5.4% reduction in body weight-p<0.0001. Mean HbA1c decreased from 8.5±2.7% to 6.0±1.8%, p<0.0001 and the percent of individuals with HbA1c in the diabetic range dropped from 76.3% to 27.5%. These changes were accompanied by marked improvements in cardiovascular risk factors, including total cholesterol (3.92±1.02 to 3.13±0.80 mmol/l; p<0.0001) and triglycerides (2.11±0.82 to 1.54±0.51 mmol/l; p<0.0001) and modest reductions in systolic and diastolic blood pressure (p<0.05). The remarkable improvement in glycemic control and lipid profile in participants suggests that a lifestyle modification intervention targeting weight loss may be highly effective for early diabetes treatment and prevention in Mongolians. vandanb@pbrc.edu