Biochemistry & Analytical Biochemistry

Trop-2 protein over-expression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

International Conference on Clinical Chemistry & Laboratory Medicine

October 17-18, 2016 Chicago, USA

Bignotti Eliana

University of Brescia, Italy

Posters & Accepted Abstracts: Biochem Anal Biochem

Abstract:

Background: endometrial cancer is the most common gynecologic malignancy in developed countries. Trop-2 is a glycoprotein involved in cellular signal transduction and is differentially over-expressed relative to normal tissue in a variety of human adenocarcinomas, including endometrioid endometrial carcinomas (EEC). Trop-2 over-expression has been proposed as a marker for biologically aggressive tumor phenotypes. Methods: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001-9 by laparotomy for EEC. Clinicopathologic characteristics including age, stage, grade, lymphovascular space invasion, and medical co-morbidities were correlated with immunostaining score. Univariate and multivariate analyses were performed for overall survival, disease-free survival and progression-free survival in relation to clinical parameters and Trop-2 protein expression. Results: Clinical outcome data were available for 103 patients. Strong Trop-2 immunostaining was significantly associated with higher tumor grade (p=0.02) and cervical involvement (p<0.01). Univariate analyses showed a significant association with reduced disease-free survival (DFS) (p=0.01) and a trend towards significance for overall and progression-free survival (p=0.06 and p=0.05, respectively). Multivariate analyses revealed Trop-2overexpression and advanced FIGO stage to be independent prognostic factors for poor DFS (p=0.04 and p<0.001, respectively). Conclusions: Trop-2 protein over-expression is significantly associated with higher tumor grade and serves as an independent prognostic factor for DFS in endometrioid endometrial cancer.

Biography :

Email: bignottieliana@gmail.com