Oral Health and Dental Management

The viability of optimization methods of bone regeneration: PRF, doxycycline, bovine bone compared to autogenous bone graft- Histomorphometric study in rats

9^th International Conference on Dentistry and Dental Implants

May 09-10, 2016 New Orleans, USA

Ronaldo Celio Mariano, Eliel Scarpioni Do Lago, Sabrina Ferreira and Idelmo Rangel Garcia Junior

Federal University of Alfenas, Brazil

Posters & Accepted Abstracts: Oral Health Dent Manag

Abstract:

The 10% doxycycline gel and the PRF had a good effect on filling of critical defects in rat calvaria, favoring the formation of bone tissue. This study aimed to investigate the effect of fibrin-rich plasma, Bio-Oss, doxycycline gel and autogenous graft on bone defects in the calvaria of rats. A critical-size defect of 5-mm diameter was performed in the calvaria of 48 rats. These animals were divided into 6 groups of 8 animals each, according to the treatment received: autogenous clot, fibrin-rich plasma, doxycyxline gel, Bio-Oss and autogenous bone. The animals were euthanized after 30 and 60 days. Bone regeneration was evaluated by histomorphometric analysis. The mean percentages of new bone were statistically similar between group�??s autogenous bone, bovine bone, doxycycline and PRF at 30 days (29.95%, 26.15, 29.79 and 28.12%) and 60 days (43.46, 40.34, 41.58 and 47.75% ± 5.78). These groups showed statistically higher values to the blood clot autogenous group at 30 days (13.78%) and 60 days (20.82%). We conclude that the use of bovine bone, doxycycline or PRF behaved similarly to autogenous bone graft, still considered the gold standard for filling bone defects.

Biography :

Email: ronaldocmariano@gmail.com