Oral Health and Dental Management

The effect of bisphosphonate on dental implant osseointegration in rabbits: Micro-CT analysis

18^th Asia-Pacific Dental and Oral Care Congress

November 21-23, 2016 Melbourne, Australia

Raniah Abdullah Saleh Al Eid

King Saud University, Saudi Arabia

Posters & Accepted Abstracts: Oral Health Dent Manag

Abstract:

Introduction & Objective: Dental implants are widely accepted as a successful means of replacing missing teeth. Dental implant osseointegration depends on many factors affecting bone quantity and quality. Bisphosphonate (BP) application is proposed to enhance this osseointegration. Experimental researches to date on the systemic (intravenous) administration of BP for improving implant fixation is insufficient for clinical application. The purpose of our study is to examine the effects of systemically administered BP (zoledronic acid) on the osseointegration of dental implants inserted in rabbit�??s femurs. Materials & Methods: Twenty-two (22) healthy New Zealand white rabbits were used in the study. All rabbits received insertion of custom made titanium alloy cylindrical threaded dental implants in medial side of the distal end of each femoral bone. Rabbits were randomly assigned into study and control groups. The study group received intravenous zoledronic acid in a dose of 0.1 mg/kg in single doses 1 week before implant insertion surgery, immediately before the implant insertion procedure and 1 week after implant insertion. Each group was divided into 3 subgroups according to duration of observation after dental implants insertion: 3 weeks, 6 weeks and 12 weeks before sacrifice. Rabbit�??s femur bone samples including the implants were subjected to micro-CT analysis for bone volume, bone implant contact and bone mineral density measurements. The data were statistically analyzed. Results: Micro-CT analysis showed that bone volume was significantly increased in the study group after 12 weeks than in control counterpart. Bone mineral density was significantly higher in study group after 3 weeks and 12 weeks period but not significantly high in 6 weeks period. Bone implant contact showed significant increase in study group after 12 weeks than control group but it was not significant within 3 weeks or 6 weeks periods. Conclusion: Intravenous BP (zoledronic acid) administration in perioperative period of dental implant surgery in a low dose is effective in enhancing bone formation, increasing bone mineral density and decreasing bone remodeling around dental implants in the process of osseointegration.

Biography :

Email: dr.raniahaleid@hotmail.com