Journal of Allergy & Therapy

Spectrum of mast cell activation disorders

7^th International Conference on Allergy, Asthma and Clinical Immunology

September 14-15, 2016 Amsterdam, Netherlands

Theoharis C Theoharides, Anastasia I Petra, Smaro Panagiotidou, Julia M Stewart and Pio Conti

Tufts University School of Medicine, USA

Posters & Accepted Abstracts: J Allergy Ther

Abstract:

Mast cell (MC) activation disorders present with multiple symptoms including flushing, pruritus, hypotension, gastrointestinal complaints, irritability, headaches, concentration/memory loss and neuropsychiatric issues. These disorders are classified as cutaneous and systemic mastocytosis with a c-kit mutation and clonal MC activation disorder, allergies, urticarias and inflammatory disorders and mast cell activation syndrome (MCAS), idiopathic urticaria and angioedema. MCs are activated by IgE but also by cytokines, environmental, food, infectious, drug and stress triggers, leading to secretion of multiple mediators. The symptom profile and comorbidities associated with these disorders, such as chronic fatigue syndrome and fibromyalgia are confusing. We propose the use of the term �??spectrum�?? and highlight the main symptoms, useful diagnostic tests and treatment approaches.

Biography :

Email: theoharis.Theoharides@tufts.edu