Journal of Nanomedicine & Nanotechnology

Spatiotemporally Fabricated Core-Shell Nanofibers for Regulated Delivery of Biomolecules in Wound Therapeutics

10^th International Conference on Nanomedicine and Nanotechnology in Health Care

July 25-27, 2016 Bangkok, Thailand

Shoba Ekambaram, Rachita Lakra, Manikantan Syamala Kiran and Purna Sai Korrapati

CSIR-Central Leather Research Institute, India

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The physiological and pathological complexity of the wound healing process makes it more challenging to design an ideal tissue regeneration scaffold. Precise scaffolding with high drug loading efficiency, efficient intracellular efficacy for therapeutic delivery, minimal nonspecific cellular and blood protein binding and maximum biocompatibility forms the basis for ideal delivery system. This paper describes a combinational multiphasic delivery system where in biomolecules are delivered through fabrication of coaxial electrospinning of different biocompatible polymers. The ratio and specificity of polymers for specific biofunction is optimized and the delivery system is completely characterized with reference to structural integrity of Bromelain (debridement enzyme) and Salvianolic acid B (angiogenesis and re-epithelialization). The in vitro release profile illustrated the sustained release of debriding protease and bioactive component in a timely fashion. In addition, in vivo studies confirm the efficacy of the fabricated scaffold. Our results, therefore opens up new venue for designing combinational multiphasic delivery system of biocatives to enhance wound healing.

Biography :

Email: shobaekambaram@gmail.com