James L Ratcliff
Rowpar Pharmaceuticals, Inc., USA
Posters & Accepted Abstracts: Oral Health Dent Manag
Increasingly, human saliva is used as a valuable biomarker to the identification of oral and systemic diseases. Also, it can serve as powerful activators for a certain class of antimicrobials in the treatment of oral malodor and oral diseases. This presentation describes the composition and characteristics of human saliva amenable to use for diagnostic and therapeutic purposes. The role of saliva in human health is briefly reviewed and its potential use with a novel chemotherapeutic is examined. Research is described wherein the activation and release of active (gaseous chlorine dioxide) from a novel therapeutic a) occurs rapidly and without a measurable interval of induction, b) results from the oxidative reduction and consumption of amino acids and volatile sulfur compound precursors, and c) generates twice the available actives as that generated from conventional formulations. Implications for future use of salivary biomolecules as biomarkers of disease and oral malodor are discussed as well as implications for future research of using the measurement of the consumption of salivary biomolecules by antimicrobials in disease diagnosis and treatment.