Shahid Beheshti University of Medical Sciences, Tehran, Iran
Posters & Accepted Abstracts: Oral Health Dent Manag
Recently, tissue regeneration has become promising treatment for bone defects which eliminates donor site morbidity. There are little evidences on tissue engineering application in alveolar cleft defects. The purpose of this study was to compare the outcomes of intra and extra oral autogenous bone grafts and buccal fat pad (BFP) derived mesenchymal stem cells (MSCs) with the gold standard method in human alveolar cleft bone defects. Ten patients with unilateral cleft lip and palate were selected for this study and anterior maxillary cleft defects were treated as the following 3 groups: group 1, anterior iliac crest (AIC) and collagen membrane; group 2, lateral ramus cortical bone (LRCP) and MSCs mounted on freezed dried bone allograft (FDBA); and group 3, AIC, MSCs cultured on natural bovine bone mineral (NBBM) and collagen membrane. The amount of new regenerated bone was measured using cone beam computed tomography 6 months post operation. Higher mean amount of new bone formation in 3rd group suggests that the use of BFP derived MSCs with anterior iliac crest can increase bone regeneration capacity in alveolar cleft bone defects. In addition, there was no statistically significant difference between groups.