Pharmaceutica Analytica Acta

Recent advances in gastro retentive drug delivery systems

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Prabhakar Reddy Veerareddy

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Oral route is generally the preferable route of administration but it has certain restrictions for those drugs which absorb from particular region of gastrointestinal tract. The bioavailability of drugs was improved by increasing their retention time in the stomach and several approaches are described which are used to increase the gastric retention time of the dosage form. Controlled released dosage forms were used to improve therapy with several essential drugs. The development processes faces several physiological problems like the failure to control and localize the system within the desired region of the gastrointestinal system. This unpredictability leads to erratic bioavailability. Inclusion of the drug in gastroretentive drug delivery systems (GRDDS) can remain in the gastric region for several hours which could considerably extend the gastric residence time of drugs and get better bioavailability, reduce drug misuse, and increase the solubility of drugs which are less soluble in high pH environment. Gastroretention would make easy local drug delivery to the stomach and proximal small intestine. Gastroretention might aid to provide greater availability of new products and consequently improve therapeutic activity thus benefiting patients. Various gastroretentive approaches designed are high density, floating, super porous hydrogels, mucoadhesive, expandable, unfoldable, and magnetic systems. GRDDS is a loom to prolong gastric residence time, targeting site-specific drug release in upper gastro intestinal tract. These systems will help in constantly releasing the drug before it reaches the absorption window, thus ensuring best possible bioavailability.