Journal of Carcinogenesis & Mutagenesis

Prognostic factors for surgical outcome and survival in women treated for borderline ovarian tumors

15^th Asia Pacific Oncologists Annual Meeting

September 05-06, 2018 Tokyo, Japan

Medhat Esam Eldin Helmy, Gamal Amira, Amany Abd-Elhameed Abou-Bakr, Nabih Elsebaey Elkhouly, Haitham Aboali Hamza and MohamedZakaria Sayer Dayer

Menoufia University, Egypt
Cairo University, Egypt

Scientific Tracks Abstracts: J Carcinog Mutagen

Abstract:

Data of 92 patients diagnosed with Borderline Ovarian Tumors (BOTs) during the period from 2010 to 2017 in the National Cancer Institute (NCI), Cairo University, Egypt were retrospectively evaluated median follow up period was 42 months. The mean age at diagnosis was 42.7 years. Histopathology was serous in 63%, mucinous in 28.3%, and endometrioid in 3.3%. 65 patients (70.7%) had stage 1A disease, 17 patients had stage 1B disease (18.5%), 4 patients had stage 1C disease (4.3%), 2 patients had stage 2 disease (2.2%) and 4 patients had stage 3 disease (4.3%) at diagnosis. 49 patients (53.3%) underwent fertility sparing surgery, of which 19 patients underwent Unilateral ovarian cystectomy, 5 patients underwent Bilateral ovarian cystectomy, 25 underwent Unilateral salpingo-oopherectomy. 43 patients (46.7%) underwent radical surgery including hysterectomy, bilateral salpingo-oopherectomy. 39 patients had micropapillary disease (42%) and 2 patients had micro invasive disease (2.2%) on histopathology. 6 patients (6.5%) had peritoneal implants of which 1 was invasive and 5 were non-invasive. Recurrence rate in the entire study group was 18.5%, 17.6% among patients underwent radical surgery and 82.4% among patients underwent fertility sparing surgery. 12 of the recurrences (70.6%) were borderline whereas 5 were invasive (29.4%). Stages 1A and 1B had significantly higher disease-free survival than other stages. Patients with micro invasion had significantly lower free disease-free survival 10.5 (9.52–11.5) vs 77.6 (70.9–84.1). Radical surgery had significantly higher FDS than fertility sparing surgery 75.8 (70.2–81.4) vs 68.5 (58.2–78.8).

Biography :

Medhat Esam Eldin Helmy is working in Menoufia University, Egypt

Email: medhathelmy@hotmail.com