Pharmaceutica Analytica Acta

Preparation and evaluation of a novel dosage form for nail delivery

17^th Annual Congress on Pharmaceutics & Drug Delivery Systems

September 20-22, 2018 Prague, Czech Republic

Flavia Laffleur

University of Innsbruck, Austria

Scientific Tracks Abstracts: Pharm Anal Acta

Abstract:

Predominantly, the majority of fungal infections (dermal and nail) are caused by dermatophytes, such as Trichophyton rubrum known as one of the most prominent. Among fungal infections, nail infections or onychomycosis exhibit the most difficulties and limitations in their treatment. Onychomycosis affects around 5-10% of the population in the world. Onychomycosis is a common infection of the nail caused by dermatophyte affecting mostly toenails in adults being associated with limited treatment options. In this study, novel dosage forms were prepared and evaluated for their suitability in treatment of onychomycosis. Films were prepared comprising polymeric excipients such as chitosan, (hydroxypropyl) methyl cellulose, hydroxyethyl-cellulose, carboxymethylcellulose according to solvent evaporation method. Developed formulations were evaluated in terms of physical appearance, stability and adhesiveness. Furthermore, skin and nail irritation studies were conducted. Five potential formulations (F1-F5) were designed while F1 and F4 exhibited the most promising results in terms of stability with 26 min and 40.67 min, respectively, and suitability in nail application. F1 as the most favorable dosage form revealed with 2.9438 kg/m/s in terms of adhesive force the most adhesive properties in contrast to the other preparations. All formulations were found to be non-skin irritating and safe to use. Taken together, these findings suggest novel designed films containing polymeric excipients as a fruitful platform for the treatment in onychomycosis.

Biography :

Flavia Laffleur is an Assistant Professor and a Senior Researcher of Drug Delivery in the Department of Pharmacy at LFU Innsbruck, Austria. She has published over 68 publications and gave oral presentations on several international conferences. From 2010 until 2013, she has completed her Doctoral thesis focused on smart drug delivery systems. Since 2013, she is a Senior Researcher at the Department of Pharmaceutical Technology in Innsbruck. Since 2017, she is a Researcher at the MIT, in Boston, Massachusetts. She has received several awards, including Lesmüller-Stiftung award and the Galenus Foundation Technology Award. Currently, her research focusses on mucosal drug delivery as well as smart delivery systems to overcome biological barriers.

E-mail: Flavia.Laffleur@uibk.ac.at