Journal of Nanomedicine & Nanotechnology

Preparation and characterization of dexketoprofen tromethamol loaded Eudragit® RS 100 nanoparticles

Nanotechnology Congress & Expo

August 11-13, 2015 Frankfurt, Germany

Ahmet Alper �zt�rk, Evrim Yenilmez and Yasemin Yazan

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

Nonsteroidal antiinflammatory drugs (NSAIDs) also called nonsteroidal anti-inflammatory agents/analgesics (NSAIAs) or nonsteroidal anti-inflammatory medicines (NSAIMs) are a class of drugs which provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and anti-inflammatory effects in higher doses. The most prominent members of this group, aspirin, ibuprofen and naproxen are all available as over-the-counter drugs in most countries. Arylpropionic acids are a group of NSAIDs currently produced in the racemic form. Dexketoprofen tromethamol is the dextrorotatory enantiomer of ketoprofen formulated as tromethamine salt. Dexketoprofen tromethamol?s distribution half-life and elimination half-life are 0.35 and 1.65 hours, respectively. Eudragit polymers which are acrylic/metacrylic acid esters act as polyelectrolytes regulated by percentage of charged (quaternary ammonium) and non-ionized (ether) groups in their structures. Eudragit RS� 100 is a poly-(ethyl acrylate, methyl methacrylate, chloro trimethyl ammonium ethyl methacrylate) copolymer. It is insoluble at physiological pH values but undergoes swelling in water. Eudragit RS� 100 is commonly used for enteric coating of tablets and preparation of controlled-release drug forms and represents a prototype for dispersion of drugs. Polymeric nanoparticles prepared by spray-drying method and characterized for controlled oral delivery of dexketoprofen tromethamol was aimed in this study.

Biography :

Ahmet Alper �zt�rk received BA in June 2013 at Anadolu University, Faculty of Pharmacy. He started the PhD program in September 2013. He is working as a Research Assistant at the Department of Pharmaceutical Technology at Anadolu University since 2014. He has participated in the ERASMUS Internship Program at University of Cagliari, Italy in 2011.