Pharmaceutica Analytica Acta

Polymeric nanoparticle engineering: From temperature-responsive polymer mesoglobules to gene delivery systems

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Emi Haladjova1, Natalia Toncheva-Moncheva1, Margarita D Apostolova1, Barbara Trzebicka2, Andrzej Dworak2, Petar Petrov1, Ivaylo Dimitrov1, Stanislav Rangelov1 and Christo B Tsvetanov1

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

A novel approach for the preparation of nano- and microcapsules in aqueous solutions by using thermo responsive polymer (TRP) templates (mesoglobules) is described. The method comprised three steps: Formation of mesoglobules, coating the templates by seeded radical copolymerization, followed by core dissolution and core removal upon cooling. When mesoglobule entraps bio-macromolecules during the process of their formation, it makes it possible to load a controlled amount of bioactive compounds without covalent attachment. Special attention is paid to the mesoglobule dissolution upon cooling, as well as their loading efficiency. Details on the outer shell formation and the possibilities for targeting ligands incorporation and control of the shell porosity are discussed. Finally, the seeded radical copolymerization was used for covering DNA complexes with cationic copolymers bearing TRP blocks. This review is an attempt to convince researchers of the promising perspectives for using mesoglobules as potential reservoirs, carriers, and transferring agents for biologically active substances.