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Pharmacological screening of oxazines for epilepsy
International Conference on Bio-Pharmaceuticals, Biosimilars & Pharma Industry
February 28 - March 01, 2019 Osaka, Japan
Mathew George
Pushpagiri College of Pharmacy, India
Scientific Tracks Abstracts: Pharm Anal Acta
Abstract:
Oxazines are six membered heterocyclic compounds with oxygen and nitrogen as heteroatoms in the ring. Many isomers exist depending on the relative position of the heteroatoms and relative position of the double bonds. Oxazine derivatives are promising heterocyclic with extensive biological properties. Oxazine derivatives have been reported to possess antifungal, antibacterial, cytotoxic, antiviral and analgesic activity. Twenty five oxazines derivatives synthesized and all structures characterized spectrally, CHN analysis done and subjected to screen for anticonvulsant property by two methods classical maximal electroshock (MES) and by chemically induced methods. Epilepsy is featured by recurrent unprovoked seizures. Acute toxicity of the compounds studied and experiments proceeded with safe dose. The structure-activity relationship among these compounds has also been discussed. This study highlighted the properties of new compounds with different functional groups exert promising antiepileptic properties, which may be more effective and selective, and possibly with less side effects. Compounds with halogen exhibited more activity.
References
1. Mathew George, et al. (2016) A Review on Screening of Novel Oxazine Derivatives for Certain Pharmacological Activities. Ijppr.Human; 6(1): 1-6.
2. Vogel H G (2002) Anticonvulsant activity. In: Vogel WH, Scholkens BA, Sandow J, Muller G, Vogel WF Drug Discovery and Evaluation of Pharmacological Assays: 423-87.
Biography :
Mathew George is currently working as Professor and Principal/Director of Pushpagiri College of Pharmacy, India. He has completed his Post-doctoral studies at USA and France. He has published more than 250 scientific research articles and authored different National and International text books. He has been awarded Best Teacher Pharmacist award by Kerala State Pharmacy Council.
E-mail: mathewlincg@yahoo.com