Journal of Nanomedicine & Nanotechnology

One step prepared albumin mineralized optical/MRI/CT trimodal probe for in vivo tumor targeted imaging

11^th International Conference and Expo on Nanoscience and Molecular Nanotechnology

October 20-22, 2016 Rome, Italy

Chao Xu, Yunjing Luo, Yaling Wang and Xueyun Gao

Beijing University of Technology, China
Institute of High Energy Physics - CAS, China

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Multiple model imaging is often employed to complement each other for obtaining more overall information in disease diagnosis. However, the multiple model imaging reagent based on ultra-small nanoparticles which could be fast cleared, still are rarely reported. Hence, we developed the optical/CT (computed tomography)/MR (magnetic resonance) triple modal probe using biomineralization method with BSA as a template. In this research, the optimized synthesis conditions, the chemical and physical properties of the as-prepared nanoparticles were investigated; the biocompatibility and tissue distributions of the nanoparticles were also investigated. The result showed that the as-prepared AuGd nanoparticles (NCs) showed ultra-small size, good biocompatibility and it was predominantly cleared by renal clearance. The optical/CT/MR imaging investigation indicated that the nanoparticles showed good optical, CT and MR imaging abilities. Through conjugating the AuGd NCs with vitamin M (FA), we also achieved the targeted tumor optical/CT/MR imaging in vivo, and the nanoparticles did not induce potential toxicity in vivo.

Biography :

Email: xuc@ihep.ac.cn