Pharmaceutica Analytica Acta

Novel hydrogels based on new dendritic polymers as antimicrobial carrier systems

8^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 07-09, 2016 Madrid, Spain

Garcia Monica C, Cuggino Julio C, Rosset Clarisa I, Strumia Miriam C, Manzo Ruben H, Alovero Fabiana L, Alvarez Igarzabal Cecilia I and Jimenez-Kairuz Alvaro F

Universidad Nacional de Cordoba, Argentina
Instituto de Desarrollo Tecnologico para la Industria Quimica, Argentina

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Hydrogels are usually defined as a crosslinked polymeric network having the capacity of holding large amount of water within its porous structure. Those comprise an important class of biomaterials specially used for drug delivery applications, due to their biocompatibility, good rheological and bioadhesive properties, high capacity of loaded drug and modified-release behaviors. This work reports the development of an antibacterial delivery system, under hydrogel form, based on a novel biocompatible dendronized polyelectrolyte (DP) as a carrier of ciprofloxacin (CIP). The ionic complexes of DP-CIP were formed by acid-base reaction using the high density of acid groups of the dendronized polymer and the amine groups of the ciprofloxacin drug. Hydrogels based on DPCIP were easily prepared and showed excellent mechanical properties without dermal irritation for topical administration. A slow and diffusion-controlled in-vitro release of CIP towards simulated physiological fluids was observed. The release performance could be attributed to the ion exchange phenomenon, revealing that the release of CIP from these hydrogels was appropriate, in terms of both magnitude and velocity. In-vitro bacterial growth inhibition assay showed a significant CIP activity, corresponding to 38 and 58 % compared to that exhibited by CIP hydrochloride solution at similar CIP concentrations, against S. aureus and P. aeruginosa, respectively. In addition, the high biocompatibility of hydrogel was demonstrated by in-vivo skin irritancy test. The hydrogel based on DP-CIP showed particularly promising properties that could be exploited for the treatment of topical and mucosal opportunistic infections in human or veterinary applications.

Biography :

García Mónica C has completed 5 years degree at Universidad Nacional de Córdoba, Argentina. She is a Pharmacist and is working on her PhD thesis at the Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Particularly, she works in the Group of Pharmaceutical Technology led by Rubén H. Manzo, PhD. The goal of her work is to develop and study new pharmacotherapeutic systems, including novel drug delivery systems, in order to improve the efficacy and safety of Chagas disease treatment.