Pharmaceutica Analytica Acta

Novel biodegradable hydrogel sponge composite containing curcumin and honey for chronic diabetic foot ulcers

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Munira M Momin

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

A biodegradable superporous wound healing sponge composite of chitosan and alginate incorporated with curcumin and honey was successfully developed. The hydrogel base has good capacity to donate moisture or absorb exudates. The ancient system of Indian medicines has recommended curcumin and honey combination as an effective wound healing remedy wound healing. The proposed sponge composite contains curcumin (3%w/v) and honey (10%v/v). The morphology and chemical structure was characterised by SEM and FTIR. A 32 factorial design was adopted to optimize the formulation variables, i.e., Amount of Chitosan (X1) and Amount of Alginate (X2). The selected dependent variables, i.e., swelling capacity (Ysc) and drug diffusion rate (Ydiff) showed statistically significant effect. The swelling capacity, moisture loss, folding endurance, tensile strength, water vapour permeation (41.12g/m2/h), biocompatibility, bioadhesion (20?0.2 mg force), in-vitro biodegradation, in-vitro drug diffusion and wound healing properties were studied to confirm the applicability of the developed hydrogel composite for chronic diabetic foot ulcers. The developed sponge composite delivers the drug slowly for the period of 12 days along with biodegradation. As the X1 increased, swelling capacity and strength of the composite was increased. The highest swelling capacity was 111.05?05%. This optimized batch also showed elongation 26.53 mm and tensile strength 4323 gm/mm2 and maintained its integrity. The batch F9 presented slow and controlled drug diffusion (69.11%) over a period of 20 days. The wound contraction results revealed that faster healing pattern of curcumin composite sponge is due to presence of chitosan which enhances the granulation and epithelization process.