Pharmaceutica Analytica Acta

Neutralization of inflammation induced by peroxidized phospholipids by non-antioxidant compounds

17^th Annual Congress on Pharmaceutics & Drug Delivery Systems

September 20-22, 2018 Prague, Czech Republic

Valery Bochkov

University of Graz, Austria

Keynote: Pharm Anal Acta

Abstract:

Oxidized phospholipids (OxPLs) represent an emerging class of lipid mediators generated by enzymatic or non-enzymatic oxidation of esterified polyunsaturated fatty acids. Multiple studies have characterized OxPLs as inducers of proinflammatory, procoagulant and proangiogenic mediators in a variety of cells and tissues. Accumulating evidence suggests that OxPLs induce these proteins through signaling pathways that are different from those utilized by the majority of physiological or pathological inducers of inflammation, blood clotting and angiogenesis. This presentation will discuss specific intracellular signaling mechanisms mediating induction of interleukin-8, tissue factor and VEGF by OxPLs. As a proof of principle for selective inhibition of OxPLinduced inflammation a new chemical scaffold will be described that selectively inhibits production of interleukin-8 by OxPLs but has minimal effects on the action of recognized inflammatory agonists such as cytokines (TNFa, IL-1b) or bacterial products (lipopolysaccharide). The study suggests new approaches for pharmacological protection against oxidative stress using non-antioxidant compounds.

Biography :

Valery Bochkov has completed his PhD degree in Biochemistry from the Cardiology Research Center in Moscow, Russia, followed by Post-doctoral Research at the Basel University Hospitals in Switzerland. Since 2000, he has performed research on Biology of Oxidized Lipids at the Institute of Vascular Biology and Thrombosis Research at the Medical University of Vienna. Since 2014, he is a Professor of Molecular Pharmaceutics at the Institute of Pharmaceutical Sciences, University of Graz, Austria. He has published more than 125 papers in peer-reviewed journals.

E-mail: valery.bochkov@uni-graz.at