Pharmaceutica Analytica Acta

Nanoparticles for drug delivery: From Camptothecin to Paclitaxel

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Lopez-Romero J M2, Baeyens J M1, Prados J C1, Melguizo C1, Leiva M C1, Martinez-Ferez A1, Casado M A2, Contreras-Caceres R2 and Diaz A2

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Solubility in water and hydrophilic solvents is necessary for biological applications of active compounds. However, organic actives are commonly non-soluble in these media and need to be chemically modified or loaded into nanoparticles in order to increase their bioavailability. , Camptothecin and derivatives like irinotecan, topotecan, diflomotecan, rubitecan and grimatecan are topoisomerase inhibitors that shows very little solubility in water. Only the hydrochloride form of some of them shows an improve solubility. To maintain the maximum activity of the topoisomerase inhibitors the design of new structures is needed, but also alternative administration methods need to be evaluated. In particular, oral administration of some of the newer camptothecin analogues has also shown promising results. On the other hand, paclitaxel and taxanes are a widely used family of anticancer drug that presents very poor solubility and stability in aqueous solution. Encapsulation in cremophor or albumin particles needs to be done for the intravenous administration of the actives. Here we present our results on the preparation of silica nanoparticles of isoindolo[2,1-b]isoquinoline, as a model with similar chemical structure to that of camptothecin. This hybrid material gives very good bioavailability of the active in aqueous systems. Moreover, we present the synthesis, by sonication, of tripalmitin solid lipid nanoparticles of paclitaxel. These nanoparticles were tested against tumoral cell lines MCF-7 (mama) and A549 (lung). AFM, SEM/TEM, Raman and NMR techniques were used to elucidate the structure and composition of the particles and emulsions. Complete results will be reported in the communication.

Biography :

J.M. Lopez-Romero is professor at the University of Malaga from 2000. Postdoctoral studies were carried out at the University Pierre et Marie Curie (Max Malacria, Paris VI, France) and University of Houston (Chengzhi Cai, USA). He is founder and director of Icon Nanotech S.L., a Spanish Spin-Off company dedicated to nanotechnology and natural products. He has published more than 50 papers in reputed journals. Research interest includes synthesis of natural products and macromolecules, and their applications on nanotechnology and cosmetics.