Biochemistry & Analytical Biochemistry

Light-activated reagents for double-dtrand DNA cleavage with built-in selectivity for hypoxic cancer tissues

International Conference and Exhibition on Biochemical & Molecular Engineering

October 07-08, 2013 Hilton San Antonio Airport, TX, USA

Igor V. Alabugin

Scientific Tracks Abstracts: Biochem Anal Biochem

Abstract:

This talk will present light-activated molecular systems for switchable pH-gated ds DNA-cleavage. These hybrid compounds combine potent DNA-photocleavers with pH-regulated components derived from basic amino acids or peptides. The pH-gating amines undergo protonation at the pH threshold which separates cancer and normal cells. This change leads to an extraordinary increase in the efficiency of therapeutically important double-strand DNA cleavage, far exceeding that for the natural enediyne calicheamicin, the most potent of natures anticancer agents.

Biography :

Igor V. Alabugin received his Ph.D. degree from the Moscow State University at the age of 25. After a postdoctoral study at the University of Wisconsin-Madison, he joined the Department of Chemistry and Biochemistry of the Florida State University in 2000, where he is currently a Full Professor. He coauthored 93 peer-reviewed publications and several patents. He co-organized two international conferences and presented 79 keynote, plenary and invited talks at conferences, universities and companies. He is a reviewer for 45 journals and 7 funding agencies. His research combines organic chemistry with biochemistry and materials science for design of photochemical double-stranded DNA cleavage agents with built- in selectivity to cancer cells, development of pH-gated biological processes, discovery of fast and selective reagents for bioorthogonal chemistry, functionalization of nanomaterials, and construction of precisely cut and functionalized graphene ribbons.