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Levosalbutamol Versus Salbutamol in the Treatment of Acute Exacerbation of Asthma Patient
2nd International Conference on Pharmaceutics & Novel Drug Delivery Systems
20-22 February 2012 San Francisco Airport Marriott Waterfront, USA
Md Atiar Rahman
Scientific Tracks Abstracts: Pharm Anal Acta
Abstract:
Levosalbutamol improved pulmonary function significantly more than racemic salbutamol. Though salbutamol is an effective treatment of acute exacerbation asthma but its use is associated with undesirable side effects like tachycardia and hypokalemia Objective To compare the efficacy and tolerability of Levosalbutamol and salbutamol for the treatment of acute exacerbation of asthma in children aged 8 to 15 years. Methods A randomized double blind clinical study included 60 children of either sex between ages of 8 to 15 years, known case of asthma and was attended in the emergency department as acute exacerbation . The study medicine was salbutamol 2.5 mg and levosalbutamol 0.63 mg, and the total drug volume was 2.5 ml and nebulized over a period of 8-10 minutes. Forced expiratory volume in 1st second was measured using Manual Promoter. Child was made to use the Spiro meter in a standing position 3 times and best of the three values was taken.