Journal of Nanomedicine & Nanotechnology

Irbesartan nanosuspension: An approach for dissolution rate enhancement by statistical optimization

8^th World Medical Nanotechnology Congress & Expo

June 08-09, 2016 Dallas, USA

Chetan H Borkhataria and Dhaval V Patel

B K Mody Government Pharmacy College, Indial

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Out of new chemical entities being generated through drug discovery process around the world, more than 40% are poorly water soluble. Nanosuspension is a remedy to poor solubility of drug as is most suitable for the compounds with high log P value, high melting point and high dose. By using nanosuspension, one can enhance the dissolution of drug simply by forming colloidal dispersion of nano-sized drug particle with suitable stabilizer. Irbesartan is used as anti hypertensive agent and is a non-peptide specific competitive antagonist of the angiotensin II receptor (AT1 subtype). Studies were carried out with a view to select suitable polymer as stabilizer PVP K30, Poloxamer 407, Lutrol F-68. Irbesartan nanosuspension can be prepared using a wet-milling method with Poloxamer 407 as hydrophilic polymer stabilizer. Nanosuspension was prepared by media milling method. The effect of homogenization speed, homogenization time and media milling time on the mean particle size was studied. The FTIR study indicated that irbesartan showed no chemical interactions with excipients. Nanosuspension was characterized for particle size, polydispersivity index, Zeta potential and evaluated for Q10 min release, solubility invitro drug release study. Selection of the amount of ZrO2 beads and Poloxamer 407 as stabilizer are critical to achieve a particle size close to 233 nm and greater than 81.87% drug dissolved in 10 min. The results for optimized batch were obtained as follows: homogenization time is 2 hrs, homogenization speed is 6000 rpm and milling time is 18 hrs.

Biography :

Email: hetanborkhataria@gmail.com