Biochemistry & Analytical Biochemistry

Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type-2 diabetes mellitus

International Conference on Biochemistry

October 10-12, 2016 Kuala Lumpur, Malaysia

Eman T Mehanna

Suez Canal University, Egypt

Scientific Tracks Abstracts: Biochem Anal Biochem

Abstract:

The intestinal fatty acid binding protein (FABP-2) is expressed in enterocytes and binds with saturated and unsaturated long-chain fatty acids. FABP-2 Ala54Thr polymorphism was reported to have an influence on lipid metabolism. This study aimed to assess the relation of this polymorphism with peripheral atherosclerosis combined with type 2 diabetes mellitus in an Egyptian population. The study included 100 diabetic patients with peripheral atherosclerosis and 100 control subjects. The Ala54Thr polymorphism was analyzed by PCR-RFLP. FABP-2 level was measured by ELISA technique. FBG, fasting serum insulin, HbA1c lipid profile, BMI, systolic and diastolic blood pressure were all determined. The Thr54 allele had higher frequency among the patients group (p=0.002). The heterozygote Ala54/Thr54 and the rare Thr54/Thr54 genotypes showed significant increase in BMI and FABP-2. Carriers of Thr54/Thr54 genotype had significantly decreased HDL-C. Carriers of Thr54/Thr54 genotype had significantly higher systolic and diastolic blood pressure than carriers of both Ala54/Ala54 and Ala54/Thr54 genotypes. FABP-2 level had positive correlation with BMI, systolic and diastolic blood pressure and negatively correlated with HDL-C. The Thr54 allele of FABP-2 Ala54Thr polymorphism was associated with increased incidence of peripheral atherosclerosis combined with type-2 diabetes mellitus in the studied population.

Biography :

Eman T Mehanna is a Lecturer of Biochemistry and Molecular Biology at the Faculty of Pharmacy, Suez Canal University, Egypt. She has 6 internationally published papers.

Email: emanmehanna22@yahoo.com