Oral Health and Dental Management

Genetic and biochemical changes in the mandibular condylar cartilage as a function of administration of growth factors and mandibular advancement

7^th Global Dentists and Pediatric Dentistry Annual Meeting

March 31- April 01, 2016 Valencia, Spain

Amol S Patil

Bharati Vidyapeeth Dental College and Hospital, India

Posters & Accepted Abstracts: Oral Health Dent Manag

Abstract:

Growth of the mandibular condylar cartilage (MCC) has always been an area of keen interest for the orthodontists, especially the adaptation of the MCC to forward mandibular positioning. Mandibular forward positioning solicits cellular and molecular responses in the temporo-mandibular joint of growing and non-growing animals leading to condylar growth. In contrast, few reports have demonstrated that such adaptive responses to forward mandibular positioning were negligible or non-existent in non-growing animals. It is of importance that our clinical treatment is based on sound scientific understanding of the tissue responses to different treatment modalities. Thus, this presentation will focus on the genetic and biochemical changes in the MCC in young as well as adult rabbits with mandibular advancement. Growth factors are peptides that stimulate cellular growth, differentiation and proliferation. Role of growth factors on the mandibular condylar cartilage has not been investigated thoroughly. Thus, the administration of growth factors with and without mandibular advancement in young and adult rabbits and its influence on condylar growth at the genetic (Vascular endothelial growth factor, SOX-9, Decorin, Matrix gla protein, Matrix metalo-proteinases), biochemical (Proteoglycans) and histologic level will be discussed.

Biography :

Email: amolp66@yahoo.com