Journal of Nanomedicine & Nanotechnology

Formulation of Fluconazole as topical antifungal gels by micro-sponge based delivery systems

16^th World Medical Nanotechnology Congress

September 03-04, 2018 Tokyo, Japan

V Rama Mohan Gupta

G Pulla Reddy College of Pharmacy, India

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The purpose of present work was to formulate fluconazole loaded micro-sponge-based topical delivery system for modified release. Micro-sponges with varied drug-polymer ratios were prepared by emulsion solvent diffusion technique using ethyl cellulose as release retard material. Prepared micro-sponges were studied for particle size and physical characterization. Scanning Electron Microscopy (SEM) images showed the micro-sponges porous and spherical in shape. The micro-sponges were then incorporated in carbopol gel and evaluated for pH, viscosity, spreadability, drug content, in vitro release. The in vitro drug release showed that micro-sponges with 1:1.5 drug-polymer ratios (F3) were more efficient to give sustained release of 74.2% at the end of 8 hrs. All the micro-sponge gel formulations (i.e. F1-F10) showed better results like pH between 6.5-7.0, viscosity between 25,030-47,390 cps, spreadability 2-4 cm/s and drug content of 76.20±0.02% to 96.41±0.01%. Hence, the fabricated micro-sponge based formulation of fluconazole would be anticipation and promising substitute to conventional therapy of skin infections.

Biography :

V Rama Mohan Gupta has his expertise in the development of spherical agglomerates, co-crystals, proniosomes, microspheres and different types of nanocarrier systems to target different organs. He has worked on many solubility enhancement techniques, formulation development and in vitro-in vivo characterization studies for various drugs during his PhD research work. He is serving as a Principal and HOD of pharmacy colleges from past 15 years. He is serving as the President-Elect of India-Telangana ISPOR Regional chapter, involved in disseminating the knowledge of pharmaco-economics, drug use and patient centered outcomes. He has published nearly 84 research publications in various national and international journals.

E-mail: vrmgupta_05@yahoo.co.in