Pharmaceutica Analytica Acta

Formulation of anti-cancerous novel drug from Tephrosia purpurea

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Gnanaraja R

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

The drug discovery from medicinal plants (natural source) involves a polygonal attitude combining botanical, phytochemical, biological,and molecular techniques. The drugs from Tephrosia purpurea to provide new and important leads against various pharmacological targets against cancer and other diseases. The TLC and HPLC were used to separate the different phytocompounds (i.e. flavonoids, phenols, steroids and saponin) from Tephrosia purpurea and the different concentration (i.e. 0.05, 0.10, 0.15, 0.20 μg) of separated phytocompounds treated against Diethyl nitrosamine (DENA) and alcohol induced hepatocellular carcinoma in Swiss albino mice. The maximum reduction of liver cancer marker and antioxidant marker were found formulated drug from Tephrosia purpurea as well as histopathology studies were exhibited maximum improvement against hepatocellular carcinoma. The formulated drug of T. Purpurea may be used as pharmacotherapeutics with other phytomedicines for overcoming of liver complications and disorders, further studies are needed for establishment of bioactive compounds of extracts and their mechanism to control liver cancer as well as liver disorders.