Biochemistry & Analytical Biochemistry

Endothelium biomarkers endocan and thrombomodulin levels in isolated Coronary Artery Ectasia

International Conference on Biochemistry, Proteomics & Bioinformatics

May 16-17, 2018 Singapore

Sadettin Selcuk Baysal

Sanliurfa Training and Research Hospital, Turkey

Posters & Accepted Abstracts: Biochem Anal Biochem

Abstract:

Aim: Endothelial dysfunction may play an important role in the evolution of Coronary Artery Ectasia (CAE). Endocan and Thrombomodulin (TM) are two biomarkers released from the endothelium that are associated with dysfunction. We aimed to evaluate the levels of these markers in patients with isolated CAE. Method: 32 patients with isolated CAE and 35 sex and age-matched control patients with normal coronary angiograms were enrolled. Serum endocan and TM concentrations were measured with an enzyme-linked immunosorbent assay kit. Result: The basal characteristics of the two groups were similar. Both endocan (1.19±0.18 vs. 1.07±0.15 ng/ml; p=0.006) and TM (687.28±150.85 vs. 571.27±171.23 pg/ml; p=0.007) were significantly increased in the CAE group compared to controls. However, no significant differences were detected in the concentration of these markers when we grouped the subjects according to the Markis classification. Conclusion: We found higher endocan and TM levels in isolated CAE patients. However, these markers were not associated with CAE severity as assessed using the Markis classification. The results suggest that these markers play an important role in the development of isolated CAE. sselcukbaysal@hoptmail.com