Hereditary Genetics: Current Research

Effect of urate, an end product of purine nucleosides catabolism, on sperm function

5^th World Congress on Epigenetics and Chromosome

November 15-16, 2018 Istanbul, Turkey

Saleem Ali Banihani

Jordan University of Science and Technology, Jordan

Keynote: Hereditary Genet Curr Res

Abstract:

Since beginning of the 60s, several studies have revealed the effect of urate, an end product of purine nucleosides catabolism, on semen quality and sperm function; though, this effect has not yet been collectively studied. Here, we systematically discuss the effect of urate on semen quality and sperm function and thus on sperm parameters (sperm motility, viability, morphology and sperm DNA oxidation). In conclusion, urate contributes to enhancing and protecting sperm viability, motility, morphology and sperm DNA damage, hence, contributes to protecting the ability of sperm to achieve fertilization. Mechanistically, this contribution is achieved primarily by counteracting the detrimental effect of nitrating agents and oxidizing agents, and enhancing the biochemical activity of certain enzymes in sperm. In contrast, high concentration of urate may induce negative effects on sperm parameters.

Biography :

Saleem Ali Banihani has completed his PhD from Cleveland Clinic-Cleveland State University collaborative program in the field of Clinical Chemistry and Molecular Medicine. Currently, he is the Vice Dean of Faculty of Applied Medical Sciences at Jordan University of Science and Technology. He has published more than 33 papers in reputed journals, mainly in the field of Andrology.

E-mail: sabanihani@just.edu.jo