Biochemistry & Analytical Biochemistry

Effect of anti-diabetic drugs and adipokine levels

International Conference on Biochemistry

October 10-12, 2016 Kuala Lumpur, Malaysia

Rabia Farooq, Shajrul Amin and Sabhiya Majid

Government Medical College, India
University of Kashmir, India

Posters & Accepted Abstracts: Biochem Anal Biochem

Abstract:

T2DM is a consequence of complex interactions among multiple genetic variants and environmental risk factors. This complex disorder is also characterized by changes in various adipokine. In this study, our objective was to estimate the levels of adiponectin, leptin and resistin (ALR) in Type 2 Diabetes Mellitus (T2DM) patients, besides studying the effect of various drugs on their levels. Study participants included 400 diabetic and 300 normal patients from the Department of Endocrinology and Department of Biochemistry, Government Medical College Srinagar. Subjects were categorized under various groups i.e., (group one: metformin treated), (group two: Glimepiride treated) and cases were also categorized as obese with T2DM (group A), obese without T2DM (group B) and T2DM only (group C). The serum ALR levels were estimated by ELISA (Alere), and also biochemical parameters were evaluated before and after treatment. Adiponectin levels were found to be significantly lower in T2DM cases as compared to controls (12±5.5 vs. 22.5±7.9 μg/ml), while as leptin and resistin levels were found to be significantly higher than controls (14.3±7.4 vs. 7.36±3.73ng/ml) (13.4±1.56 vs. 7.236±2.129 pg/ml). Taking the effect of drugs into consideration, the effect on adiponectin and resistin levels were found to be highly significant in group two before and after treatment (11±5 vs. 19.2±4.5 μg/ml) (13.6±2.5 vs. 7.3±2.9 pg/ml), while as more effect was observed in leptin among group one (metformin) treated cases (27±15 ng/ml vs. 15±15 ng/ ml). Further the adiponectin levels were found to be significantly lower in group B, while as leptin and resistin levels were found to be significantly higher among obese cases when compared to T2DM cases only. Glimepiride also shows more effect on FBG, HbA1c% levels while as metformin shows more effect on lipid profile levels. From the study, it can be concluded that ALR levels are affected by use of anti-diabetic drugs among which glimepiride shows more effect on adiponectin and resistin levels while leptin gets affected more by metformin. It can also be proposed that ALR levels are not affected by diabetes only, suggesting that their alterations in T2DM may be due to obesity as we observed more ALR changes in obese cases when compared to T2DM cases and so there might be an important link between adiposity and Insulin resistance.

Biography :

Email: rabiajan4uuu@gmail.com