Pharmaceutica Analytica Acta

Drug release and permeation studies of Diclofenac sodium from buccal tablets

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Ayhan Savaser, Ozgur Esim, Cansel K Ozkan, Cetin Tas and Yalcın Ozkan

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Diclofenac sodium (DS) is a nonsteroidal anti-inflammatory agent useful in the treatment pain and swelling associated with rheumatic disorders since 1974. DS can be considered as one of the few NSAIDs of ?first choice? in the treatment of acute and chronic painful and inflammatory conditions (1). In this study DS buccal tablets were prepared with different kinds of polymers namely chitosan, carbopol, HPMC and formulations? in vitro drug release results compared with in vitro and ex vivo permeation results. Materials: Diclofenac sodium (DS) was a gift from Deva Pharm. Co. (Istanbul, Turkey) and mannitol was a gift from Eczacıbaşı Baxter(Turkey). The following materials were used as received: Carbopol 941 (B.F.Goodrich Chemical Company, USA), cellulose membrane ( Travenol Lab. Inc., USA), chitosan (medium molecular weight) and HPMC (Viscosity of 4% solution 250C; 4000 cps) (Sigma-Aldirch, USA), microcrystalline cellulose 90 M (Penwest Pharm. Co.,USA), Spray Dried Lactose (FlowLac 100) (Meggle Pharma Excipients & Technology (Wasserburg, Germany), Colloidal Silicon Dioxide (Aerosil 200) (Evonik, Germany), sucrallose (Kimetsan, Turkey). Preparation of the Buccal Tablets: The formulations compositions of buccal tablets were given in Table I. Each tablet contains 25 mg of DS. Before direct compression, all of the ingredients were screened through sieve and then thoroughly blended in mortar with pestle. The powder was compressed using 8.0-mm punch and dies set, on tablet compress machine (Erweka AR 400, Germany). Conclusion: Polymer concentration affects the drug permeation from both cellulose membrane and bovine buccal mucosa by affecting the drug release (5). The best release profiles were observed in formulations used with chitosan and HPMC. Due to all of diclofenac sodium was released in 8 hours and better permeability results. D10 formulation which contains 15 % chitosan and 20% HPMC can be a suitable formulation for buccal use.