Pharmaceutica Analytica Acta

Development of alginate-chitosan nanoparticles utilizing W/O emulsion technique for transdermal delivery of Rabeprazole

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Tarek A Ahmed and Khalid M El-Say

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Objectives: First; to develop rabeprazole (RP)-alginate core coated chitosan nanoparticles (NP) utilizing W/O nanoemulsion technique. Second; formulation of transdermal patches loaded RP-NP that avoid drug peroral acid sensitivity and first pass effect. Method: The influence of six factors on RP-NP formulation was investigated using Plackett-Burman (PB) design. The studied factors were considered for their effect on particle size (Y1) and loading efficiency (Y2). Formulation optimum desirability was identified; a proposed formulation prepared and characterized. In vitro permeation of the prepared NP compared with RP was studied. Transdermal patches loaded drug or RP-NP were prepared and characterized. Patches ex vivo permeation through rat skin was studied, kinetic analysis and permeation mechanism were investigated. Results: Chitosan, oil phase and surfactant to oil ratios had significant effects on Y1 while, Y2 was significantly affected by the same variables affecting Y1 and span80-tween80 ratio. Scanning electron microscope imaging illustrated sphericity of the NP. The optimized RP-NP exhibited sustained release pattern. The prepared patches showed minimal patch to patch variations. Patches loaded RP-NP exhibited substantial skin permeability and controlled drug release, and were in favor of Fickian diffusion. Conclusion: Transdermal patches loaded RP-NP is effective drug delivery and alternative to drug peroral route.