Pharmaceutica Analytica Acta

Development and optimization of fast dissolved tablets containing high dose of extremely bitter drug: Taste masking and enhancement of drug dissolution using sugar based excipients

4^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 24-26, 2014 Hilton San Antonio Airport, San Antonio, USA

Emad B. Basalious, A. Abdullah and M. Ibrahim

Posters: Pharmaceut Anal Acta

Abstract:

The purpose of this research was to mask the intensely bitter taste of aceclofenac and to formulate an orodispersible tablet of the taste-masked drug for enhancement of drug dissolution. Preformulation studies were performed for taste masking of the drug which includes granulating the drug with B-cyclodextrin. A full factorial design was employed for the optimization and to explore the effect of several sugar based excipients such as diluents type (X1; Galen?IQ and Prosolve?), type of superdisintegrant (X2; Croscarmellose sodium, Crospovidon? and Sodium starch glycolate) and concentration of superdisintegrant (X3; 10% and 20) on the release extent of the drug from orodispersible tablets. The formulated orodispersible tablets were assessed for in vitro wetting time, in-vitro disintegration time, in-vivo disintegration time, in vitro release, hardness, friability and drug content. The components of the optimized orodispersible tablet formulation were aceclofenac, B-cyclodextrin, citric acid, Prosolve?, 10% Crospovidon?, Pearlitol?, Aspartam (3%), Pruv? (1%) and Aerosil 200? (1%). The optimized formulation showed rapid in vitro disintegration (about18 sec.), rapid in vitro release rate of 84.3% in 5 minutes and acceptable taste sensation. It could be concluded that a promising taste masked orodispersible tablet of aceclofenac with enhanced drug dissolution was successfully designed.

Biography :

Emad B. Basalious is a Associate professor of pharmaceutics and Industrial Pharmacy and Faculty of Pharmacy at Cairo University, Egypt.