Pharmaceutica Analytica Acta

Development and evaluation of Solanum nigrum extract loaded PLGA microspheres for antiulcer potential

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Prashant Sahu

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

The apex aspire of current study was to design & fabricate Solanum nigrum extract loaded PLGA (Polylactic-glycolic acid) sustained released microspheres to appraise antiulcer bustle in Acetyl Salicylic acid induced ulcer rat model. Solvent evaporation method was engaged to fabricate the Solanum nigrum extract loaded microspheres. Scanning electron microscopy and Optical microscopy was employed for size, shape, architecture and distribution investigation of microspheres. Formulations containing Solanum nigrum loaded PLGA sustained released microspheres administered orally to the animal model. Solanum nigrum loaded microspheres significantly decreased free-acidity, total-acidity, ulcer index and gastric volume and considerably increased the pH in Acetyl Salicylic acid model. The results of histopathology of stomach (after administration of formulation) presume the zenith potential of sustained released PLGA microspheres loaded Solanum nigrum extract opening the new eon for the better management of ulcer predicament.

Biography :

Prashant Sahu has completed his B.Pharm & M.Pharm from SIPS College Sagar MP India. He has done his masters degree in Quality Assurance and currently working as Research Scholar in Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (MP) India in the field of Nanotechnology based Drug delivery system under the guidance of Sushil Kumar Kashaw. Prashant Sahu has won 2 International oral paper presentation awards and 2 National oral paper presentation awards with 3 National poster presentation award.