Pharmaceutica Analytica Acta

Design of modified release multi particulate drug delivery system for anti Parkinsons drugst

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Prashant P Raut and Shrikant Y Charde

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

The present work aimed to design gastroretentive modified release multi-particulate system for Levodopa and Carbidopa for better therapeutic outcome and bioavailability. Multiparticulate system was designed wherein drug loaded Levodopa and Carbidopa pellets, manufactured using extrusion spheronization technique, were coated with four successive coatings: the protective layer (ethyl cellulose), two effervescent layers (tartaric acid layer and sodium bicarbonate layer) and polymeric layer (Eudragit RL 100) for entrapping the gas evolved. The impact of composition and manufacturing parameters of pellets on their micromeritic properties, floating characteristic and in vitro dissolution properties were studied. The designed pellets showed excellent floating ability (more than 24 h) and physical characteristics. Amount of sodium bicarbonate and Eudragit RL 100 layered onto pellets influenced floating ability and in vitro drug release rate. Pellets coated with protective layer [weight gain: 3% (w/w)], effervescent layers [weight gain of tartaric acid and sodium bicarbonate layer was 8% (w/w) and 12% (w/w) respectively] and gas-entrapped polymeric membrane [Eudragit RL 100, weight gain: 20% (w/w)] showed sustained drug release up to 24 hrs. Both the drugs showed similar release profile which was confirmed by calculation of similarity factor. The designed pellets followed zero-order drug release kinetics. The floating characteristics and in vitro release depends on amount of sodium bicarbonate layered on pellets and coating level of ethyl cellulose and Eudragit RL 100. Floating pellet using multilayer approach is a feasible approach for the controlled delivery of Levodopa and Carbidopa combination. These results need to be further confirmed by in vivo techniques.

Biography :

Prashant P Raut is a research scholar at Department of Pharmacy, BITS Pilani, India, one of the country?s most reputed technical university. He is currently a Senior Research Fellow under the UGC-BSR scheme of Government of India. He is currently working on a research project entitled ?Design and Development of Multiple Unit Drug Delivery Systems for Combination of Drugs?.